Cholesterol and Heart Disease: Is There a Connection?
Although high serum cholesterol in young adults is known to be a the association between change in cholesterol levels and CVD outcomes. The finding that the normal group's mean cholesterol level (±SD) was . Ten- Year Mortality from Cardiovascular Disease in Relation to. Relation Between Serum Total Cholesterol Level and Cardiovascular . High serum TC levels are associated with coronary heart disease in.
If you were playing Devil's Advocate, you could argue that this represents a preconceived view of the authors regarding the role of cholesterol, rather than the open, unbiased mind you would hope for in the spirit of scientific enquiry.
That said, many important scientific breakthroughs happened due to the efforts of individuals who challenged a prevailing orthodoxy of thinking. In general, the UK media provided fairly balanced reporting, presenting both sides of the argument — supporting the findings, but with critical views from other experts.
Study says there's no link between cholesterol and heart disease - NHS
What kind of research was this? It has long been thought that cholesterol is a key cause of the fatty build-up in arteries atherosclerosis that causes heart disease. However, the researchers say there are contradictions to this view. Recent research has suggested that total cholesterol becomes less of a risk factor for all-cause or cardiovascular mortality the older people get.
Less is known about LDL specifically and that's what this research aimed to look at. A systematic review is the best way of gathering evidence from cohort studies that have looked at the link between an exposure or risk factor and an outcome.
However, the strength of a review's findings is only as good as the studies they include. In cohort studies, it is often difficult to directly attribute an outcome to a specific cause, and there is always the potential that other factors are influencing the outcome.
Cholesterol and Heart Disease – What’s the Evidence?
What did the research involve? The researchers searched one literature database PubMed in December to identify English-language cohort studies that had included a general population sample aged 60 and over.
Studies had to have taken baseline measures of LDL cholesterol and then followed participants up over time, looking at the link with all-cause or cardiovascular mortality.
Three authors reviewed potential studies and extracted data. From an initial 2, hits, 19 publications, covering 30 cohorts and including 68, participants, were included.
The majority of studies were excluded outright, as they didn't seem to contain anything relevant in the study title or abstract summary. The other reasons for exclusion were non-English language, participants not being representative of the general population, not measuring LDL cholesterol at baseline, and not giving separate data for older adults or looking at mortality outcomes. What were the basic results? That is, as LDL cholesterol went down, all-cause mortality went up — higher LDL was apparently linked to lower all-cause mortality.
On January 2,men aged 25 through 39 years were employed by the Peoples Gas Company. Of these, The cohort for this study comprises men who were free of clinical diabetes mellitus and CHD and had complete baseline data.
The standardized baseline survey included medical history, physical examination, 3 blood pressure measurements averaged for analyses, and serum cholesterol levels measured using the method described by Abell et al.
Study says there's no link between cholesterol and heart disease
Verification included checks with the National Death Index since its inception in Vital status of every man in the PG cohort is known. The focus here is on 69, men aged 35 through 39 years at baseline with complete data on baseline risk factors and who were free of diabetes mellitus and MI.
To assess trial eligibility, the first screening included measurements of blood pressure and serum cholesterol levels; current smoking by questionnaireincluding number of cigarettes per day; and conditions for exclusion, ie, drug treatment for diabetes mellitus and previous hospitalization for MI.
The researchers found that making minor dietary changes in this case, replacing a few regularly eaten foods with better fat-quality alternatives reduced cholesterol and could potentially reduce future risk of heart disease. Researchers raise questions Newer research questions the role cholesterol plays in the development of heart disease.
A systematic review published in found that people over 60 years old who have high LDL cholesterol live as long or longer than people with low LDL. The researchers suggest reevaluating the guidelines for heart disease prevention in older adults.
The team chose studies from only one database and only those published in English. More research on cholesterol, particularly dietary cholesterol, needs to be done. Both of these changes are associated with increased risk of heart disease, according to the American Heart Association.
Trans fats also offer no nutritional value. Partially hydrogenated oils PHOs are the main source of trans fat in our diets. Inthe U.